![]() This GBM model providesĮxplanation of the effects mediated by the tumour microenvironment Within the hypoxic core of the tumour mass, while moreĭifferentiated cells are mainly localized along the peripheral and We recently investigated the relationshipĮxisting between Glioblastoma (GBM) stem cells and their niche,ĭefining the theory of three-concentric layers model for GBM mass.Īccording to this model, GBM stem cells reside preferentially “hypoxic niche” plays a crucial role in controlling CSC molecularĪnd phenotypic profile. In this paper, we report studiesįrom many authors demonstrating that hypoxia or the so called Identified in particular brain tumor niches fundamental for Moreover, in the last years, these cells have been Phenotype, combined with self-renewal and chemotherapy resistanceĬapacity. (CSCs) or tumor initiating cells (TICs) that possess an immature ![]() Originate from a sub-population of cells named cancer stem cells Tumors arising in the central nervous system are thought to ![]()
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